Buy Lortab 10/325mg Online Lortab 10/325mg is a prescription medication combining hydrocodone bitartrate (10mg) and acetaminophen (325mg). It is commonly used to treat moderate to severe pain. Hydrocodone is an opioid pain reliever, while acetaminophen is a non-opioid analgesic and fever reducer that enhances the pain-relieving effects of hydrocodone.